Silver-Ion-Containing Solution Aids in Chronic Wound Healing

Chronic wounds pose a significant challenge in the field of healthcare, often complicated by bacterial infections. Clinicians seek sustainable alternatives to systemic antibiotics to manage chronic wound infections effectively. One such alternative that has garnered attention is the use of silver, known for its historical and contemporary antimicrobial properties. Silver-containing dressings have shown promise in wound care, with meta-analyses indicating reductions in wound size. In this article, we explore a novel approach—utilizing a silver-ion-containing solution that gradually releases ionic silver into the wound. This innovative solution shows potential as an adjunctive therapeutic for chronic wounds.

Addressing the Need for Alternative Approaches to Chronic Wound:

Given the vulnerability of chronic wounds to bacterial infections, healthcare practitioners strive to minimize bacterial growth without relying on repeated courses of systemic antibiotics. Historically, silver has been recognized for its antimicrobial properties, and recent advancements have seen the use of silver-containing dressings. These dressings have demonstrated their ability to reduce wound size, presenting an exciting avenue for improving chronic wound healing. In this context, we investigate the use of a novel silver-ion-containing solution that offers a unique approach to combat chronic wound infections.

Purpose of the Study:

The primary objective of this study is to gather observational data concerning the use of a silver-ion-containing solution as an adjunctive therapeutic for chronic wounds. By exploring this innovative approach, we aim to understand its impact on chronic wound healing and its potential as an effective treatment option.


The study involved the treatment of six patients with chronic wounds, all of whom received a novel silver-ion-containing solution called SilverStream® from EnzySurge, Inc., Tel Aviv, Israel. This treatment was administered at least once weekly over a 5-6 week study period within a single wound care center. The patient group consisted of both males and females aged 47-81, presenting chronic wounds associated with venous disease and diabetic foot disease. These patients continued to receive standard therapies for their specific wound types. During the pilot study, the ionic silver solution was topically applied using a standard 3mL syringe and a 22-gauge needle, with an average total volume of 9-12mL.

Investigation and Outcomes:

Remarkably, none of the patients experienced any adverse reactions during the study, marking a crucial aspect of safety in the utilization of the silver-ion-containing solution. More significantly, all six patients reported an improvement in their wound condition, demonstrating the potential of this innovative approach.

Upon initiating treatment, 5 out of 6 patients displayed clinical signs of infection, including erythema, purulent drainage, pain, and non-granulating wound beds. However, 5-6 weeks after their first treatment, none of the patients exhibited signs of infection—a striking 100% reduction. The reduction in wound size varied from 6.6% to a complete healing of the wound. The average reduction in wound size was an impressive 70%, and 3 out of 6 patients experienced full wound healing during the pilot study.


The findings from this pilot study underscore the potential of the silver-ion-containing solution as a powerful adjunctive therapeutic for chronic wounds. It showcases the ability of the solution to diminish signs of infection, reduce wound size, and facilitate wound healing. The promising outcomes of this investigation warrant further exploration through a prospective randomized clinical trial. This could potentially pave the way for an innovative and effective treatment approach for chronic wounds, significantly enhancing patient outcomes and quality of care in wound management.